background image

Nor Adrenalin

Isoprenaline

Adrenalin

Effect on :

decreases heart rate due to 

increased blood pressure 

that induces a reflex rise in 

vagal activity by stimulating 

the baroreceptor

s

If atropine is given before 

Noradrenaline, or the vagas 

is cut ,or the patient is in 

shock then there will be 

tachycardia

.

increase heart rate.

increase heart rate.

1. Heart rate

increase contractility and 

stroke volume.

 

The reflex compensation 

doesn't affect the positive 

entropic effect of 

Noradrenaline

.

increase 

contractility and 

stroke volume

increase 

contractility and 

stroke volume.

2. Force of

contraction

little or no effect on 

cardiac output (due 

to weak beta

1

effect)

increase cardiac 

output .

increase cardiac 

output .

3. Cardiac

output :

Increase

(least with 

Noradrenaline).

Increase

Increase

4. Myocardial

oxygen 

consumption 

Increased

Increased

Increased

5. Conductivity

causes constriction 

(i.e. increase total 

peripheral 

resistance TPR) 

through αlpha 

action .

dilate vessels going to 

the skeletal muscles & 

liver

 

the effect, therefore, is 

a decreasing in total 

peripheral resistanc

e

more evident with 

Iso. (β₂ action).

dilate vessels going to 

the skeletal muscles & 

liver

 

the effect, therefore, is 

a decreasing in total 

peripheral resistanc

e

(β₂ action)

6.Blood vessels

of skeletal 

muscles :

constrict skin and 

mucus membrane 

arterioles (αlpha 

action).

has no effect 
because there are 
no beta receptors in 

the skin& mucus 
membrane 

constrict skin and 

mucus membrane 

arterioles (αlpha 

action).

7. Skin blood

vessels:

 Comparison of effect of Adrenaline , Isoprenaline , Noradrenaline


background image

Nor Adrenalin

Isoprenaline

Adrenalin

Effect on :

Constrict

 

arterioles (αlpha 

action

 

The same of the 

skin.

has no effect 

because there are 

no beta receptors

The same of the 

skin 

Constrict

 

arterioles (αlpha 

action)

 

The same of the 

skin.

8. Renal blood

vessels :

produce 

venoconstriction 

which leads to 

increased venous 

return .

produces dilation of 

veins which leads to 

decreased venous 

return.

produce 

venoconstriction 

which leads to 

increased venous 

return .

9. Veins

increases systolic 

and diastolic blood 

pressure (alpha 

action).

Isoprenaline may 

increase systolic 

pressure slightly but it 

greatly reduces the 

diastolic pressure & the 
mean arterial pressure

.

Adrenaline increases 

systolic blood pressure 

(Beta1) with slight 

decrease in diastolic 

blood pressure (Beta2 

vasodilation)

.

The mean blood pressure 

(MBP) = (diastolic + 1⁄3 pulse 

pressure) may be slightly 

increased because the increase 

in systolic pressure is much 

more than the decrease in 

diastolic pressure. So 

Adrenaline increases the mean 

blood pressure but the 

increase is less with 

Noradrenaline

.

10. Blood

pressure :

have no effect

have no effect

reduces capillary 

permeability due to 

widening of the 

endothelial cells that 

decreases the pores

.

11. Capillaries:

has no effect. 

(Because there are 

no αlpha receptors 

in the bronchiolar 

smooth muscles)

.

cause powerful 

bronchiodilation 

(β₂ effect).

cause powerful 

bronchiodilation 

(β₂ effect).

12. Bronchiolar

smooth muscle 

cause relaxation .

(αlpha₂ action)

 

cause relaxation .

 (βeta₂ action)

 

cause relaxation .

(alpha₂ and beta₂ 

action)

 

13. 

Gastrointestinal 

Tract:


background image

Nor Adrenalin

 

Isoprenaline

 

Adrenalin

 

Effect on :

 

(alpha action ) 

causes contraction.

 

(beta₂ action) 

causes relaxation

 

(beta₂ action) 

causes relaxation

 

 
 

14. Pregnancy 

uterus :

 

has little effect 

because it is not 

absorbed (causes 

severe 

vasoconstriction).

 

has no effect.

 

(alpha₁ action) 

causes contraction 

of radial muscles 

(mydriasis).

 

15. Radial 

muscles of the 

iris

 

may increase blood 

suger.

 

cause increase in 

blood suger (β₂ 

effect).

 

has significant 
hyperglycemic effect 

because it : 
increases glycogenolysis 

in the liver (beta₂ effect)  

increases the release of 
glucagon (beta₂ effect)  

Decreases the insulin 
(alpha₂ effect on Beta cells 
of Pancreas)

.

 

16. Blood 

glucose: 

(increased by 

all)

 

least increased by 

Noradrenaline

 

The increased 

Lipolysis induced 

by Isoprenaline is 

not clinically 

significant

 

initiates Lipolysis 

(through its agonist 

activity on BETA₃ 

receptors).

 

17.Lipolysis:

 

may cause 

hyperkalemia 

through alpha₁ 

effect.

 

l

ead to hypokalemia 

because the biochemical 

pump that shifts k into 

the cells is activated by 

beta₂ agonists

 

l

ead to hypokalemia 

because the biochemical 

pump that shifts k into 

the cells is activated by 

beta₂ agonists

.

 

18. Serum 

pottasium k:

 

less with 

Noradrenaline.

 

cause muscle 

tremor (beta₂ 

effect)

 

cause muscle 

tremor (beta₂ 

effect)

 

19. Muscle 

tremor :

 

has no effect

 

The release is 
inhibited (beta₂ 
effect 

The release is 

inhibited (beta₂ 

effect)

 

20. Release of 

mediators from 

mast cells :

 

 




رفعت المحاضرة من قبل: Abdalmalik Abdullateef
المشاهدات: لقد قام 10 أعضاء و 120 زائراً بقراءة هذه المحاضرة








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