Hemochromatosis liver pancreas and lymph node
The dark brown color of the liver, as well as the pancreas (bottom center) and lymph nodes (bottom right) on sectioning is due to extensive iron deposition in a middle-aged man with hereditary hemochromatosis.Rt: H&E stained section showing hemosiderin as yellow-brown finely granular pigment within hepatocytes. Lt.: same section stained with an iron stain (Prussian blue); the hemosiderin granules are deep blue.
Hemochromatosis liver
Hereditary hemochromatosis liver
Hereditary hemochromatosis. Hepatocellular iron deposition is blue in this Prussian blue-stained section of an early stage of the disease, in which parenchymal architecture is normal.Copper deposition in Descemet’s membrane of the cornea. These rings can be either dark brown, golden, or reddish-green, are 1 to 3 mm wide, and appear at the corneal limbus. With rare exceptions, they are diagnostic of inherited hepatolenticular degeneration—Wilson’s disease. This 32-year-old patient complained of longstanding difficulty speaking. He also had a tremor. Kayser-Fleischer ring
Wilson’s disease rhodanine stain This is the cirrhotic stage. This reveals accumulation of copper (redgranules) in varying degree, most pronounced in a nodular cluster of hepatocytes (left). (Rhodanine stain)
α1-AT deficiency Periodic acid-Schiff stain of the liver, highlighting the characteristic red cytoplasmic granules