Structure and function of factor VIII-von Willebrand factor (vWF) complex
Factor VIII is synthesized in the liver and kidney, and vWF is made in endothelial cells and megakaryocytes. The two associate to form a complex in the circulation. vWF is also present in the subendothelial matrix of normal blood vessels and the alpha granules of platelets. Following endothelial injury, exposure of subendothelial vWF causes adhesion of platelets, primarily via glycoprotein lb platelet receptor.d
Structure and function of factor VIII-von Willebrand factor (vWF) complex