Acute Inflammation (recruitment of neutrophils).
Acute Inflammation
Acute Inflammation
Acute Inflammation
Acute Inflammation (with pus)
Acute Inflammation
Acute Inflammation
Chronic inflammation
It is the inflammation of prolong duration (weeks or months).
It is occurred as:
Following acute inflammation.
Occurs, incidentally as active inflammation.
With tissue destruction.
With repair process.
Chronic Inflammation (Tissue destruction-Pancreas)
Chronic Inflammation (Fibrosis-pancreas)
Causes of Chronic inflammation
I - Persistent infection.
II - Prolonged exposure to potentially toxic agents.
III - Autoimmunity.
Chronic Inflammation (Lung)
Causes of Chronic inflammation
I - Persistent infection:
Bacteria.
Viruses.
Fungi.
Parasites
Chronic Gastritis
Causes of Chronic inflammation
III - Autoimmunity:
Occurs in:
Rheumatoid arthritis.
Lupus erythmatosus.
Chronic Inflammation (Rheumatoid arthritis)
Chronic Inflammation (Rheumatoid arthritis)
Chronic inflammation
Lymphocyte, macrophage, plasma cell (mononuclear cell) infiltration
Tissue destruction by inflammatory cells
Attempts at repair with fibrosis and angiogenesis (new vessel formation)
When acute phase cannot be resolved
Persistent injury or infection (ulcer, TB)
Prolonged toxic agent exposure (silica)
Autoimmune disease states (RA, SLE)
Morphological Features of Chronic Inflammation
These are characterized by:
I - Infiltration by mononuclear cells.
II - Tissue destruction.
III - Removal of damaged tissue, (healing).
Morphological Features of Chronic Inflammation
I - Infiltration by mononuclear cells:
The mononuclear cells are become predominant after 48 hours.
These include:
Macrophages.
Lymphocytes.
Plasma cells.
Eosinophils.
Mast cells.
Morphological Features of Chronic Inflammation
II - Tissue destruction
Occur due to:
Inflammatory cells.
Persistent infecting material.
Morphological Features of Chronic Inflammation
III - Removal of damaged tissue, (healing):
Occur by proliferation of small blood vessels, (angiogenesis).
Proliferation of fibroblast, (fibrosis-repair).
Granulomatous Inflammation
Clusters of T cell-activated macrophages, which engulf and surround indigestible foreign bodies (mycobacteria, H. capsulatum, silica, suture material)Resemble squamous cells, therefore called “epithelioid” granulomas with peripheral lymphocytes, fibrosis & multinucleated giant cells.
Chronic Granulomatous Inflammation
Chronic Granulomatous Inflammation
Chronic Granulomatous Inflammation
Bacterial infection (neutrophilia)
Parasitic infection (eosinophilia)
Viral infection (lymphocytosis)
Thank You
