Carbohydrates

Glycolysis

GLYCOLYTIC PATHWAY

Glucose metabolism in cells
Glycolysis:
• 1.) Phosphorylation of glucose to form glucose-6-phosphate by enzyme HEXOKINASE, GLUCOKINASE.
• Hexokinase
• Glucose glucose-6-p + ADP
• ATP Glucokinase

ISOMERASE

2.) Glucose -6- p fructose -6- p

PHOSPHOFRUCTOKINASE

3.) Fructose-6-p fructose-1,6-biphosphate
ATP


ALDOLASE
4.) fructose-1,6-biphosphate dihydroxyacetone phosphate

+

glyceraldehyde-3-p

(interchangable compound)

PHOSPHATE DEHYDROGENASE

• glyceraldehyde-3-p 1,3-biphosphoglycerate
• NAD NADH
• PHOSPHOGLYCERATE KINASE
• 6. 1,3-biphosphoglycerate 3-phosphoglycerate
• ADP ATP

MUTASE

7.) 3-phosphoglycerate 2-phosphoglycerate

ENOLASE

8.) 2-phosphoglycerate phosphoenol pyrovate


PYRUVATE KINASE
9.) Phosphoenol pyruvate pyruvate

ADP ATP

OUTCOME OF GLYCOLYSIS:

• Loss of 2 ATP molecules at the beginning

• gain of 2 NADH and 6 ATP
• formation of 2 ATP in the final step *2
• FINAL GAIN = 8 ATP