Lung Diseases 3 pdf - labs )dr nadia)

Lung Diseases 3

Third Year Class

By Dr.Riyadh A. Ali

Department of Pathology

TUCOM

Articles

• CA lung

• Squamous cell carcinoma

• Adenocarcinoma

• Oat cell (small cell) carcinoma

Squamous Cell

Carcinoma

This is a

squamous

cell carcinoma

of the

lung

that

arising

centrally in the lung (as
most

squamous

cell

carcinomas do). It is
obstructing

the

right

main

bronchus.

The

neoplasm is very firm
and has a pale white to
tan cut surface.

This is a larger

squamous

cell carcinoma

in which a

portion of the tumor
demonstrates central
cavitation, probably
because the tumor
outgrew its blood supply

This is a

squamous cell carcinoma

of the lung. It is a bulky mass

that extends into surrounding lung parenchyma.

In this

squamous cell carcinoma

at the upper left is a squamous

eddy with a keratin pearl. At the right, the tumor is less differentiated
and several dark mitotic figures are seen.

This is the microscopic appearance of

squamous cell carcinoma

with

nests of polygonal cells with pink cytoplasm and distinct cell borders. The
nuclei are hyperchromatic and angular.

The pink cytoplasm with distinct cell borders and intercellular bridges
characteristic for a

squamous cell carcinoma

are seen here at high

magnification. Obvious mitosis seen and hyperchromatism with
pleomorhism

Adenocarcinoma

This is a peripheral

adenocarcinoma

of the

lung. Adenocarcinomas
and large cell anaplastic
carcinomas tend to occur
more peripherally in lung.
The solitary white tan color
mass appearance of this
neoplasm suggests that
the tumor is primary rather
than metastatic

Adenocarcinoma

of lung known.

Seen

here

the

multifocal

variant that appears grossly (and
on

chest

radiograph)

pneumonic consolidation. Most of
the upper lobe toward the right
has

pale

tan

grey

appearance

Microscopically, the

adenocarcinoma

is composed of columnar cells that

proliferate along the framework of alveolar septae. The cells are well-
differentiated.

Microscopically showed glandular architecture . Epithelial cells are cuboidal,
columnar in type with goblet type, hyperchromatism and mitosis, moderately
differentiated

adenocarcinoma of lung

Microscopically showed glandular architecture . Epithelial cells are
cuboidal, columnar in type, moderately differentiated

adenocarcinoma of

lung.

Oat cell (small cell)

carcinoma

Arising centrally in this lung
and spreading extensively is
a

small cell anaplastic (oat

cell)

carcinoma.

The

cut

surface of this tumor has a
soft, lobulated, white to tan
appearance. The tumor seen
here has caused obstruction
of the main bronchus to left
lung so that the distal lung is
collapsed

Here is an

oat cell

carcinoma

which

spreading

along

the

bronchi. The speckled
black rounded areas
represent hilar lymph
nodes with metastatic
carcinoma

This is the microscopic pattern of a

small cell anaplastic (oat cell) carcinoma

in which small dark blue cells with minimal cytoplasm are packed together in
sheets