Pseudo Cow Pox Milker�s Nodules
DefinitioinAcute or chronic contagious viral disease of cattle and man characterized by elevated skin lesion in the teats and udder. EtiologyFamily: Pox viridae Genus: Para pox virus Species: Pseudo pox virusEpidemiologyThe disease present in many countries. - Affect cattle over 2 years. - The disease is zoonotic. �Source of infection: Infected animals. � Mode of transmission: 1- Direct and indirect contact with contaminated milker�s hands, wash clothes and teat cups 2- Transmission by bitting insects seems likely. � Susceptibility: - Freshly calved and recently introduced cattle are more susceptible. - All adult cattle in a herd including dry cows are likely to be affected. - Dose not appear to occur in animals loss Than 2 years of age. � Economic imoortance: 1- Losses occuring as a result of difficulty in milking. 2- Increase in the incidence of mastitis. � Zoonosis: The disease is transmissible to humans, infection usually resulting in development of milker�s nodules in the hand.
Clinicals signsLarge number of lesions found in the teat (100 or more in one teat)
1- Acute formLesion begin as erythema � tollowed by development of vesicle or pustule �* Rupture after 48 hours �* result in formation of thick scab bacome markedly elevated by developing granulation tissue beneath it �> after 7-10 days the scab drop off leaving a horse shoe-shaped ring of small scabs surrounding granulation tissue (wart-like granuloma) � This lesion may persist for months in the teats and udder. 2-Chronic formErythema but nrogress to yellow-gray soft scabs the scabs are readily rubbed off at milking leaving the skin corrugated. There is no pain and the lesion may persist for months. 3-Milker�s nodulesAre clinically indistinguishable from human lesions caused by octhyma virus. The lesion vary frommultiple vesicles to a sngle, indurated nodule. Diagnosis
1- lsolatin: lsotion from scabs or from fresh lesion. Isolation on teat skin culture. 2- ldentiication: By a) Large multinuctested syncytia. $ intracytoplasmic inclusions that is more common in cow pox than pseudo cow pox. b) Eectror microscope: Section of skin lasion can be diagnostic in both cow pox and pseudo cow pox. C) Fluorescent antibooy technique. d) Injection on chorioallantoic membrane of embery-onated chicken egg - only in case of cow pox give pock lesion Differential DiagnosisThe lesion of p.seudo_cowx more numerous, larger, stay for tong period and pain iess than cow pox. ContortHygenic measures such as. 1- Isolation and treatment cf affected coy.�. 2- MiIkin. of affected cow lastly. 3- Disinfection of milker�s hand and teat cups. 4- lodophor teat dip. 5- Reduce teat trauma because infection is facilitated by dscontinuty of the skin. 85
TreatmentRemoval of the scabs, which should be burned to avoid contaminating the environment �> application of an astringent preparation such as triple dye after milking and an emoHient ointement before milking.