Helicobacter pylori
Dr.ruaa Elias College of Medicine Department: Microbiology*
List of Contents:
Objectives Introduction Important properties Source and Transmission Diagnosis Diseases Treatment*
Objectives:
-H. pylori has a great ability to resist destruction by stomach acid. -Human GI tract is the only reservoir for H. pylori -H. pylori causing Chronic Gastritis and Duodenal Peptic Ulcer .This ulceration is most often chronic and recurrent and may lead to complication such as bleeding, anemia, and perforation -The students must learn all detail about the virulence factors,pathogenicity and diagnosis, treatment of these very important bacteria*
Introduction
-H. pylori is a genus of Gram-negative bacilli , bacteria in the Enterobacteriaceae family. -Transmission occurs via the fecal oral route.*
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Source and Transmission -Human GI tract is the only reservoir for H. pylori. -Transmission occurs via the fecal oral route. -There is a direct relationship between increased age and increased likelihood of H. pylori infection
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Diagnosis
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Chronic Gastritis- Symptoms: causes some nausea or upper abdominal discomfort, but in many cases the patient is asymptomatic. -Duodenal Peptic Ulcer: (H. pylori is No. 1 causative agent). Symptoms: burning upper abdominal pain; occurs 1-3 hours after meals; pain is worse at night but relieved by eating or use of anti-acids.
Diseases
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-This ulceration is most often chronic and recurrent and may lead to complication such as bleeding, anemia, and perforation. -Gastric Peptic Ulcer: similar to duodenal ulcer Gastric -Carcinoma: occurs in the setting of H. pylori
Diseases
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under the stomach mucus layer
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Treatment: -Combination of the following : -Ranitidine (H2 blocker) + Bismuth salts + Amoxycillin +Metronidazole. -Tetracycline can be substituted for amoxycillin in penicillin allergy. -Alternative combination: Clarithromycin + metronidazole.
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Summary
*References
Medical Microbiology, edited by Jawetz,E., Brooks,G.F.; Carroll,K.C.;Butet,J.S.; Mores,S.A.and Mietzner,T.A. 2010. 25 th ed. Medical Microbiology, edited by Jawetz,E., Brooks,G.F.; Butet,J.S and Mores,S.A. 2004. 23 th ed. Internet access.
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Question?
*Thanks a lot
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