Luteolysis
Corpus Luteum Formation: Luteinization
Luteinization in the process that transforms the granulosa and theca cells into luteal cells.
This process is triggered by the surge of LH at mid-cycle.
The LH surge causes profound changes in the follicles that become corpus luteum.
Luteolysis is the process by which the corpus luteum loses its capacity to synthesize and secrete progesterone.
A luteolytic agent is any factor that can reduce luteal progesterone synthesis or secretion and/or prevent the action of a luteotrophic hormone.
Luteolysis
PGF is luteolysin
PGF transported to ovary through the counter current exchange between uterine vein and ovarian artery.
This present in cow, ewe, sow.
Its important as PGF is destroyed in peripheral circulation as it passes through the lungs.
Luteolysis
not present in mare PGF gets to ovary after going through the general circulation.
mare ovary is more sensitive to PGF than other species.
Luteolysis
Oxytocin
produced by CL (large luteal cells).
receptors in uterus decline after ovulation as progesterone increases.
after 10-12 days progesterone, uterine oxytocin receptors again begin to increase.
in response to oxytocin binding to its receptor in the uterine endometrium, PGF is released.
