erythropoiesis

Hemopoiesis (Hematopoiesis)(Blood Formation)

Hemopoiesis (Gr. haima , blood + poiesis , a making) include:

Erythropoiesis
Leukopoiesis
Granulopoiesis
Monocytopoiesis
Thrombopoiesis
Lymphopoiesis

Hemopoiesis Initiated in Early Embryonic Development & Continue.

• Yolk-sac phase.
• Hepatic phase.
• Bone marrow phase.







1
2
3





1
2
3

Hemopoietic Stem Cells

pluripotent stem cell single major type of stem cells in the bone marrow that can give rise to all the blood cell types .
pluripotent stem cell potentials (committed to produce specific blood cells):
Lymphoid cells (Progenitor & Precursor)CFU
Myeloid cells (Progenitor & Precursor)CFU


Colony-Forming Units (CFUs), The progenitor cells for blood cells
Erythroid lineage of CFU-erythrocytes (CFU-E).
Thrombocytic lineage of CFU-megakaryocytes (CFU-Meg).
Granulocyte-monocyte lineage of CFU-granulocytes monocytes (CFU-GM)
Lymphoid lineage of CFU-lymphocytes of all types (CFU-L).

Hemopoietic cells

POTENTIALITY.
SELF RENEWING.
MITOTIC ACTIVITY.
INFLUENCE BY GROWTH FACTORS.
TYPICAL DIFFERENTIATION.
TYPICAL FUNCTION.

Colony Stimulating Factors CFU orGrowth factors

Cytoplasmic transition from RNA- rich to hemoglobin-filled.
Proerythroblasts
Erythroblasts
Basophilic
Polychromatophilic
Orthochromatophilic

Thank you